SLICER score nomogram.

<p>To use the nomogram, locate the first variable. Draw a line straight upwards to the Points axis to determine the number of points received for the variable. Repeat this process for other six variables and sum up the points achieved for each variable. The sum of these numbers is located on the Total Points axis, and a line is drawn downward to the survival axes to determine the likelihood of 3- or 5-year FFR. For example, a patient who has a 3 cm HCC with multifocality, liver cirrhosis, Child-Pugh A, minor vascular invasion, resection margin 5 mm, pre-surgery AFP 450ng/mL and he was asymptomatic at presentation, total points scored is 48. 3- and 5-years FFR is 16 and 8% respectively.</p

SLICER, CLIP, CUPI, BCLC, OKUDA, AJCC7 and MSKCC models as predictors of FFR.

<p>SLICER, CLIP, CUPI, BCLC, OKUDA, AJCC7 and MSKCC models as predictors of FFR.</p

Likelihood analysis.

<p>Likelihood analyses compare the SLICER with each of the various models individually, as well as its inclusion into each model, in predicting 5-year FFR. SLICER demonstrated higher adequacy index when compared to each model individually, and its inclusion in each model resulted in highly statistically significant improvements.</p

Multivariable analysis of variables associated with FFR.

<p>Multivariable analysis of variables associated with FFR.</p

SLICER calibration plots.

<p>Plots depict the calibration of SLICER in our dataset in terms of agreement between predicted and observed 3-year and 5-year FFR. Model performance is shown by the plot, relative to the 45° gray line which represents perfect prediction. The black line represents observed outcomes and the blue line represents optimism corrected outcomes generated based on our bootstrap samples.</p

Important clinical variables identified by clustering.

<p>These include pre-surgery serum AFP levels, tumor grade, tumor multifocality, tumor margin distance, vascular invasion, AJCC7 Staging, the presence or absence of symptoms at diagnosis, ECOG status, Child-Pugh class status, patient’s age at diagnosis, the presence or absence of cirrhosis in the non-neoplastic liver and tumor size. Hoeffding distance is a ranked based measure of correlation. To illustrate, this figure shows that there is a stronger correlation between vascular invasion and AJCC staging than between serum AFP and tumour grade.</p

Baseline demographic and clinical characteristics of 405 patients with resected HCC.

<p>Baseline demographic and clinical characteristics of 405 patients with resected HCC.</p